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Therefore, in IBD, in addition to providing in situ retention and sustained-release protection, it is also necessary to have certain oral stability, mucosal adhesion and inflammatory site targeting, so as to ensure the stability and local effective concentration of nanozym-hydrogel in the complex intestinal environment [145-147]

(B) Schematic illustration of the antibacterial effect of the hydrogel

doi: 10.3390/cancers15082276 2 RakicDJakovljevicVJovicNBicanin IlicMDimitrijevicAVulovicTet al

Early models relied on statistical approaches, such as n-gram models, which predict the next word in a sequence based on word co-occurrence frequencies [81]

Notably, when ingested, zeaxanthin is minimally metabolised, which might explain its significant accumulation in fatty tissues, but more predominantly in the macula [11]